The relatively small universe of human genes could grow by up to one-third, if a concerted effort to search for new genes that encode short proteins is successful. Many known miniproteins have already been shown to play key roles in cellular metabolism and disease, so the international effort to catalog new ones and determine their functions, announced last week in Nature Biotechnology, could shed light on a vast array of biochemical processes and provide targets for novel medicines.

“The microproteome is a potential gold mine of unexplored biology,” says Eric Olson, a molecular biologist at the University of Texas Southwestern Medical Center who is not involved with the new consortium. Anne O’Donnell-Luria, an expert in the genetics of rare diseases at Boston Children’s Hospital, adds that the expanded catalog could be a rich source of clues to genetic links to disease. “Everyone will be able to use this data

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Lenovo was one of the first companies to really nail 2-in-1 design, and ever since it’s been refining the formula for its top-notch convertibles. And while there are a couple small variables I’m not fully on board with for this year’s edition, there’s no doubt the new 14-inch Yoga 9i is continuing Lenovo’s excellent track record. You get superb battery life, clever (and surprisingly) powerful speakers, good performance, plenty of ports and even an optional OLED display. In short, if you’re looking for a light, long-lasting and very adaptable 360-degree hybrid, this thing belongs at the top of your list.


Now I have to admit, when I first unboxed the Yoga 9i, there was something about its design that just didn’t look right to me. And after thinking about it for a couple days, I realized Lenovo’s attempt to create a luxury aesthetic doesn’t quite go far enough. Most

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Obscenity from me. Obscenity from him. Obscene gesture from me. Obscene gesture from him. 

And then he continued his 17th hole, and I putted on the 16th. 

Tough scene, right? But before we go any further in telling you about this exchange of plesantries, you should know little rattles me. I have my opinions and enjoy sharing them, but, if we don’t see eye to eye, I still believe we can break bread afterward. To lay out this mellowness more, I once had a co-worker, in a moment of stress for him, shout at me, “Does anything ever bother you?” — to which I remember saying, “Not really.” 

But it happens. Clearly.  

Charl Schwartzel

Masters champ overhand-heaves club. But the bizarre was only starting. 


Nick Piastowski

With that, we go out to Van Cortlandt Park in the Bronx, New York on Tuesday, and

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I’ve watched “Frasier” like a dozen times and am only just noticing this.

There’s nothing like a good callback or long-running gag in a TV show.

I especially like the ones that are subtle or unexpected. (I had personally never noticed that Hopper’s daughter’s blue hair tie had appeared in every season.)

It got me thinking about some other TV callbacks and running gags that took seasons to pay off, including:


The Beetlejuice joke in Community


In the Season 1 episode “Communication Studies,” Michelle Slater pretends not to remember Britta’s name, instead calling her “bitter,” “butter,” and finally, “Beetlejuice.”

Then, in the Season 2 episode “Cooperative Calligraphy,” Britta gets a look at Jeff’s underwear and points out that he’s not wearing his usual “stripey turquoise Beetlejuice numbers.”

Finally, during Season 3’s Halloween episode, “Horror Fiction in Seven Spooky Steps,” Annie at one point says that Britta only has

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Former Miss Universe Pia Wurtzbach is excited about her forthcoming marathon in New York City, her first ever marathon race.

“It’s only 3 months before race day — and these were my thoughts before I started training and got serious about running cos I was never a runner before, and I couldn’t even stand doing any sort of cardio then. But I’ve always looked at runners with a lot of respect,” she said via her Instagram page today, July 24, sharing a photo of herself wearing her running outfit and hydration belt while looking out at Lake Como in Italy.

“But here I am getting ready for the NYC marathon @nycmarathon. It will be my first ever marathon & I’ve been training for it since late Feb,” she added.

The idea to join a marathon competition came during the New Year when she had COVID and felt “just sick and

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SAN JOSE — A new fitness center has opened its doors at a San Jose shopping center, an endeavor that offers a welcome counterpoint to the grim coronavirus-linked business shutdowns of the last two years.

UFC Fit has begun operations at Westfield Oakridge mall. The new merchant could enhance the wide-ranging makeover of the South San Jose retail hub.

“We’re ecstatic to be a part of the San Jose community and to offer our dynamic mix of premium fitness experiences under one roof to local fitness enthusiasts,” said Adam Sedlack, chief executive officer of UFC Gym, which operates the new UFC Fit outlet.

UFC Fit began operations at Westfield Oakridge in late June and was set to have a grand opening and ribbon-cutting on Friday.

Exercise equipment inside UFC Fit gym at Westfield Oakridge shopping center, 5540 Winfield Blvd. in San Jose.(Westfield Oakridge, UFC Fit)
Exercise equipment inside UFC Fit gym at Westfield Oakridge shopping center, 5540 Winfield Blvd. in San Jose. (Westfield Oakridge, UFC Fit)

The new center occupies

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COLUMBUS — One year ago, Columbus personal trainer Sam Salinas never saw herself competing in body building competitions. She said she started going to the gym a few years ago to help deal with stress and anxiety that she grew up with.

Fast forward to April when Salinas won the Miss Diva Fitness USA national title in Orlando, earning a spot in the World Beauty Fitness and Fashion (WBFF) World Championship, which takes place in August.

Salinas said she didn’t envision herself competing in these type of events.

“This last year I’ve done six shows and I’ve just really, really fell in love with being on stage and the show production part of it,” Salinas said. “It’s pretty breathtaking for me sometimes to think that I’m a national title holder and that I could have come this far, especially being from here, a little town in Nebraska. It’s pretty phenomenal

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In a new video on his YouTube channel, bodybuilder and fitness influencer Will Tennyson runs through several of the common reasons why you might not be achieving the muscle growth you want, despite seemingly doing all the right things in your workouts and diet.

Firstly, you could be underestimating how much protein you need. Tennyson compares walking into the gym without having eaten the necessary protein to walking into a strip club without any singles: “Nothing’s gonna happen.” Similarly, if you’re simply not eating enough, period, it can be hard to see results in your training. “Don’t be afraid to put on some fat when you’re trying to build muscle,” he says. “I’m not saying get fat, but you need to be in a little bit of a surplus, maybe 200 or 300 calories, to maximize muscle growth.”

That said, it’s all too easy to justify eating anything “if it

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LOS ANGELES — More than a decade after Apple disrupted the music industry and Amazon upended retail, the tech heavyweights have set their sights on a new arena ripe for change: live sports.

Emboldened by their deep pockets and eager to boost viewership of their streaming-subscription services, Apple and Amazon have thrust themselves into negotiations for media rights held by the National Football League, Major League Baseball, Formula One racing and college conferences.

They are competing to replace DirecTV for the rights to N.F.L. Sunday Ticket, a package the league wants to sell for more than $2.5 billion annually, about $1 billion more than it currently costs, according to five people familiar with the process. Eager not to miss out, Google has also offered a bid from YouTube for the rights beginning in 2023, two people familiar with the offer said.

The tech companies’ interest is a thrill for sports

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